Hantaan virus is the prototype hantavirus, identified in 1976 from striped field mice near the Hantan River in South Korea. Acute kidney injury and hemorrhagic features dominate the clinical picture rather than the pulmonary syndrome seen with American hantaviruses.
| Reservoir host | Striped field mouse (Apodemus agrarius) |
| Geographic range | China (especially Henan, Shaanxi, Heilongjiang), South Korea, Russian Far East |
| Disease syndrome | Hemorrhagic fever with renal syndrome (HFRS) |
| Case fatality rate | ~5-15% |
| Vaccine | None licensed in most countries |
| Specific treatment | None. Supportive care. |
Hantaan virus is the prototype hantavirus, identified in 1976 from striped field mice near the Hantan River in South Korea. Acute kidney injury and hemorrhagic features dominate the clinical picture rather than the pulmonary syndrome seen with American hantaviruses.
HFRS caused by Hantaan virus has been a recognized military hazard since the Korean War, when thousands of UN forces were affected. China continues to report the largest national HFRS burden globally — historically tens of thousands of cases per year, declining substantially with vaccination programs and rodent control.